This is Jeremy Smith's blog about life in Tennessee, local science and other topics of interest. Is not endorsed by and does not, of course, represent the opinion of UT, ORNL or any other official entity.
Tuesday, January 28, 2014
Let's make a Love Drug!
Oxytocin is the love hormone, the magic chemical that creates warm, fuzzy feelings of bonding, trust, empathy and cuddle cravings. When someone's level of oxytocin goes up, he or she responds more generously and caringly, even with complete strangers. This is useful of course; for example, in the bar (chatting up a hot chick), or on the battlefield (making the Islamic Insurgents fall in love with their enemy). The problem is though, that oxytocin has to be injected, which is rather inconvenient, of course on a first date ("Excuse me, Cindy, just roll up your sleeve"?), and negotiating a ceasefire on the field for such a purpose is likely to prove nontrivial. So what is needed is something that one can just spray, or pop in a drink. That could be an oxytocin activator.
Now, how about this? Last week at a neutron workshop in UCSD I chatted with Bi-Cheng Wang of UGA, with whom I wrote a paper 15 years ago on the activation of oxytocin (Boris Velikson was my postdoc who did the modeling). On the bus at the airport we decided that all we need is to design a molecule that will do the activation (cleave the precursor at Arg2-Asp13) and voila! - beautiful people wherever you need them. Drug is the Love! Anyone having problems with the wife or got an obstreperous teenager? Maybe a dog that barks too much? Send the research dollars our way!!!
[Disclaimer: for all the spoil sports - yes, I know there are ethical problems with this type of thing, and, yes, I'm not serious, and, yes, I know there is already a oxytocin nasal spray being tested for autistic kids [but an activator may be more effective anyway]].
Monday, January 13, 2014
Lose!
Norwich City - lose!
I have been a fan of yours for 47 years.
I have never wanted you to lose before.
Not against Villa at Wembley when I was a ballboy.
Not against Chelsea or Panathinaikos or Inter Milan or Bayern (and certainly not Ipswich).
But I bought a ticket to the Newcastle game on January 28th and a flight ticket back to the USA on the 29th. And now you have announced that, should you beat Fulham in the F.A. Cup 3rd round reply tomorrow night, the Newcastle game will be put back one day, to the 29th.
So tomorrow you must sink. Lose! Go Fulham!
Update: Fulham won 3-0! Whehaaay!
I have been a fan of yours for 47 years.
I have never wanted you to lose before.
Not against Villa at Wembley when I was a ballboy.
Not against Chelsea or Panathinaikos or Inter Milan or Bayern (and certainly not Ipswich).
But I bought a ticket to the Newcastle game on January 28th and a flight ticket back to the USA on the 29th. And now you have announced that, should you beat Fulham in the F.A. Cup 3rd round reply tomorrow night, the Newcastle game will be put back one day, to the 29th.
So tomorrow you must sink. Lose! Go Fulham!
Update: Fulham won 3-0! Whehaaay!
Monday, January 6, 2014
Quite Nippy
With temperatures in Knoxville presently sliding towards zero Farenheit I was trying to remember the briskest weather I have experienced. It may well be the period of January 3rd-January 18th 1985 when I lived near Grenoble, France. The temperature in the town never rose above freezing during that 18-day period. The average was around 10 degrees F and the lowest was -1F, on January 6th. Now that was in the town, and I lived 1200 ft higher, at La Grivolee (see red arrow), so the average at home would probably have been about 4F and minimum about -5F. My poor little 2CV car, nicknamed "Turbo", was just a cracked block.
Monday, December 30, 2013
Some Science Jokes for the New Year
Always game for a lame one or two, am I, so here are some science jokes for the New Year:
Two theoretical physicists are lost at the top of a mountain. Theoretical physicist No 1 pulls out a map and peruses it for a while. Then he turns to theoretical physicist No 2 and says: "Hey, I've figured it out. I know where we are."
"Where are we then?" "Do you see that mountain over there?" "Yes." "Well… THAT'S where we are."
A blowfly goes into a bar and asks: "Is that stool taken?"
A statistician is someone who tells you, when you've got your head in the fridge and your feet in the oven, that you're – on average - very comfortable.
And a couple of limericks to finish with:
A friend who's in liquor production,
Has a still of astounding construction,
The alcohol boils,
Through old magnet coils,
He says that it's proof by induction.
A mosquito was heard to complain
That chemists had poisoned her brain.
The cause of her sorrow
Was para-dichloro-
diphenyl-trichloroethane.*
*p.s. That's DDT.
Sunday, December 8, 2013
The September 1991 Mineriad
22 years ago, in September 1991, I happened to be in Bucharest. I was working in France, which had had strong links with Romania, and so after the 1989 revolution they tried to fill the vacuum and sent us over for the first post-communist Franco-Romanian Biophysics conference. But we weren't the only visitors: several thousand Jiu valley miners had been organized to come and cause trouble - the "Mineriad". Nice lads, most of them. They were wearing wellies and carried sticks (see above), slept in the parks, and shouted "Jos Iliescu" ("Down with Ion Iliescu", the President). Now, this confused me because I had thought it was Iliescu who had arranged for them to come in the first place, laying on trains etc (maybe a Romanian reader can clue me in?).
The night was full of the sweet aroma of CS-gas: Jean-Louis said he'd already experienced that, much worse, in '68. Next morning, they marched to the parliament building. We tagged along, at the back, so we missed the fighting, hundreds injured, deaths etc. They petrol bombed the parliament and the Prime Minister (Petre Roman) resigned. That was a momentous visit, I guess. The conference led to my establishing a strong association with the guys there, who throughout everything had maintained a love for science. I brought students back to Germany, France and the USA, and they did great stuff. I want to go back to Romania, back to the monasteries in Moldavia, the mountains of Transylvania, to Bucharest, and all the friends I made there. Maybe even, one day, to drink beer with miners in the Jiu valley..........
Friday, November 29, 2013
Whopping University
The USA is in chains. The chain stores are all over the USA, draped everywhere like kudzu. In the drive for efficiency everything has been automated, standardized, homogenized and cheapened. In doing so all that is left is unskilled minimum-wage jobs operating easy machines. Society is indeed on the way to a utopia where only university professors and entertainers need to work? Wait. Professors? We can downsize them, too! And make billions.
It has started already. Online courses are multiplying. Large lecture courses are being taught by low-paid adjuncts rather than faculty. Here's how to finish the job, once and for all, with the creation of Whopping University.
Firstly, you make sure that WU is created by the same banking conglomerates that own the present chains. You know the types; Goldman Sachs, Bain, 3G Capital, Falfurrias etc. They have the dosh to kick-start this and they know how to quickly standardize.
Then, you drive all other colleges out of business, retaining only their football and basketball teams. How do you do this? You offer good-looking, well-packaged degree courses for $10,000. And how, pray, is this miracle to be achieved? Using a single team of highly charismatic professors you produce online lectures for all subjects in demand and at all levels. These syllabi are well crafted, easy to follow. The lectures are good and cheap. Every student in every state has the same selection. Perfect core curricula. All lectures are followed by the students at home on their computers. The accompanying tests are fair, securely computerized, multiple choice. No more need for lecture halls, libraries, classrooms etc, anywhere in the land. No books required, everything kindled.
What about the interactive sessions? Well, you need a few of these, but these can be online, too. And you don't need professors for them, either. Students form interactive groups amongst themselves. And, a few graduates can be employed online at minimum-wage levels to provide a bit of expertise at some of these discussion sessions. Same for essay grading in the few subjects that still require those: all done via e-mail.
What about lab sessions/field-work? Hum. Indeed. Not easy to get rid of localizing that. We'd have to set up highly uniform entities, but this could be done cheaply no doubt. Little purple Whopping Lab Huts dotted over the nation with little purple WU vans taking students out to corporate-owned fields.
And there we have it. 5 million students graduating per year at $10,000 per degree means $50bn of annual revenue to be taken over. OK, that's about a tenth the size of Walmart but that's just counting the USA. Whopping University International could doubtless at least double turnover. And we can expand into high schools, too, replacing teachers with low-paid minders who just need to keep the kids watching their screens. An initial investment of about $100bn should suffice to create an unbeatable, irresistible entity capable of folding the 2000 or so colleges presently leaching students' pockets in the USA. Let's lobby congress to keep funding the scholarships though - even WU degrees need to be taxpayer funded, don't they? Those old colleges with high reputations (Harvard, Stanford etc) can franchised into the WU structure - their names would be useful - indeed, by a click and an extra debit you can say your WU degree comes from Harvard. Massive profitability after 2 years. Education for the masses! Let's take over with Whopping University!
It has started already. Online courses are multiplying. Large lecture courses are being taught by low-paid adjuncts rather than faculty. Here's how to finish the job, once and for all, with the creation of Whopping University.
Firstly, you make sure that WU is created by the same banking conglomerates that own the present chains. You know the types; Goldman Sachs, Bain, 3G Capital, Falfurrias etc. They have the dosh to kick-start this and they know how to quickly standardize.
Then, you drive all other colleges out of business, retaining only their football and basketball teams. How do you do this? You offer good-looking, well-packaged degree courses for $10,000. And how, pray, is this miracle to be achieved? Using a single team of highly charismatic professors you produce online lectures for all subjects in demand and at all levels. These syllabi are well crafted, easy to follow. The lectures are good and cheap. Every student in every state has the same selection. Perfect core curricula. All lectures are followed by the students at home on their computers. The accompanying tests are fair, securely computerized, multiple choice. No more need for lecture halls, libraries, classrooms etc, anywhere in the land. No books required, everything kindled.
What about the interactive sessions? Well, you need a few of these, but these can be online, too. And you don't need professors for them, either. Students form interactive groups amongst themselves. And, a few graduates can be employed online at minimum-wage levels to provide a bit of expertise at some of these discussion sessions. Same for essay grading in the few subjects that still require those: all done via e-mail.
What about lab sessions/field-work? Hum. Indeed. Not easy to get rid of localizing that. We'd have to set up highly uniform entities, but this could be done cheaply no doubt. Little purple Whopping Lab Huts dotted over the nation with little purple WU vans taking students out to corporate-owned fields.
And there we have it. 5 million students graduating per year at $10,000 per degree means $50bn of annual revenue to be taken over. OK, that's about a tenth the size of Walmart but that's just counting the USA. Whopping University International could doubtless at least double turnover. And we can expand into high schools, too, replacing teachers with low-paid minders who just need to keep the kids watching their screens. An initial investment of about $100bn should suffice to create an unbeatable, irresistible entity capable of folding the 2000 or so colleges presently leaching students' pockets in the USA. Let's lobby congress to keep funding the scholarships though - even WU degrees need to be taxpayer funded, don't they? Those old colleges with high reputations (Harvard, Stanford etc) can franchised into the WU structure - their names would be useful - indeed, by a click and an extra debit you can say your WU degree comes from Harvard. Massive profitability after 2 years. Education for the masses! Let's take over with Whopping University!
Friday, November 15, 2013
Science on Shaky Ground
Listen to Sally Ellingson and myself on NPR's "All Things Considered" as we discuss possible effects of recent government funding reductions for science.
Labels:
government shutdown,
NPR,
science funding,
sequestration
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