This is Jeremy Smith's blog about life in Tennessee, local science and other topics of interest. Is not endorsed by and does not, of course, represent the opinion of UT, ORNL or any other official entity.
Monday, March 31, 2014
Boat Person
My next-door neighbor in Knoxville is from Vietnam. As a teenager in the 1980s he was in a monastery, but the communist government didn't tolerate monasteries. So he became a fisherman, and decided to bide his time, learning the ropes. At the age of 19 he escaped in a boat with an engine, but was driven back by a typhoon. (Many perished in such typhoons.) One year in jail followed. My neighbor doesn't recommend communist jails. Then, he tried again, captaining a boat with 37 people, this time with no engine, and made it across the South China Sea to the Phillippines. My neighbor: one of the Vietnamese Boat People. Puts the rest of us to shame, I think. How many more stories are there like that in the leafy subdivisions of middle America?
Wednesday, March 26, 2014
Reasons to be Cheerful, Part IV
Troy Wymore: had his sarin picture appear on local TV.
Demian Riccardi: incorporated Hackamol into finding potential drugs against hypoposphatemia.
Jerome Baudry: has been strongly recommended for tenure
Xiaolin Cheng: is still publishing all sorts of stuff at a rate of knots.
Barmak Mostofian: has entropy-driven explanations of ionic liquid effects.
Hong Guo: has navigated through a huge article on a mercuric reductase
Loukas Petridis: finds water has remarkable effects on cellulose
Tongye Shen: has nailed bacterial motions.
Hanna Qi: has been grappling with huge data and found contacts.
Derek Cashman and Pavan Gatty: got great new jobs.
John Eblen and Roland Schulz: have GROMACS running fast on Intel Mics.
Benjamin Lindner: published two Markovian theory articles in JCP.
Hao-Bo Guo: has figured out redox reactions in MerA.
Liang Hong: got his fourth PRL here accepted.
Karan Kapoor: has made advances in thrombosis that we can't talk about.
Amandeep Sangha: has made a first small step to drugs for four cancers.
Sally Ellingson: graduated! Then went straight to a faculty position.
Jason Harris: successfully predicted toxicity
Xiaohu Hu: is aging gracefully
Quentin Johnson: gave us a great talk
Jing Zhou: published her cobalamine QM calculations.
Emal Alekozai: graduated!
Jerry Parks and Alex Johs: Won the big ORNL science prize.
Julia Cooper: retired. Many thanks for nearly four decades of service to ORNL.
Michael Galloway and Steve Moulton: got our new system ordered, installed, up and running.
Demian Riccardi: incorporated Hackamol into finding potential drugs against hypoposphatemia.
Jerome Baudry: has been strongly recommended for tenure
Xiaolin Cheng: is still publishing all sorts of stuff at a rate of knots.
Barmak Mostofian: has entropy-driven explanations of ionic liquid effects.
Hong Guo: has navigated through a huge article on a mercuric reductase
Loukas Petridis: finds water has remarkable effects on cellulose
Tongye Shen: has nailed bacterial motions.
Hanna Qi: has been grappling with huge data and found contacts.
Derek Cashman and Pavan Gatty: got great new jobs.
John Eblen and Roland Schulz: have GROMACS running fast on Intel Mics.
Benjamin Lindner: published two Markovian theory articles in JCP.
Hao-Bo Guo: has figured out redox reactions in MerA.
Liang Hong: got his fourth PRL here accepted.
Karan Kapoor: has made advances in thrombosis that we can't talk about.
Amandeep Sangha: has made a first small step to drugs for four cancers.
Sally Ellingson: graduated! Then went straight to a faculty position.
Jason Harris: successfully predicted toxicity
Xiaohu Hu: is aging gracefully
Quentin Johnson: gave us a great talk
Jing Zhou: published her cobalamine QM calculations.
Emal Alekozai: graduated!
Jerry Parks and Alex Johs: Won the big ORNL science prize.
Julia Cooper: retired. Many thanks for nearly four decades of service to ORNL.
Michael Galloway and Steve Moulton: got our new system ordered, installed, up and running.
Monday, March 24, 2014
Only Happy with a 15-point Lead
Sports spectatorship psychology is infuriating. Why is it that, after not caring at all for the best part of three years, it suddenly has become very important to me that the UT Vols keep progressing in the Men's Basketball NCAA tournament? Talk about fair-weather fan-dom! Also, why is it that we watch games that can rarely actually be enjoyable to watch? If we really care about the result, we can almost never be happy until the final whistle (or buzzer). You see, in soccer, my team has to be 3-0 up to be safe, and this never happens. 2-0 is not enough because the other team can score one then put the pressure on. Likewise, in basketball, if you haven't got a 15-point lead then you can never relax.
So last weekend there were two games to watch: Norwich versus Sunderland in soccer and the Vols against Mercer in the NCAA Round of 32. Norwich won 2-0, but we were never safe. The Vols, on the other hand, were 15 points or more in the lead virtually throughout. So only that game could actually be enjoyed in real time. Now, as for Michigan in the Sweet Sixteen, I doubt there will be any pleasure there until, possibly, the very, very end.
So last weekend there were two games to watch: Norwich versus Sunderland in soccer and the Vols against Mercer in the NCAA Round of 32. Norwich won 2-0, but we were never safe. The Vols, on the other hand, were 15 points or more in the lead virtually throughout. So only that game could actually be enjoyed in real time. Now, as for Michigan in the Sweet Sixteen, I doubt there will be any pleasure there until, possibly, the very, very end.
Labels:
basketball,
EPL,
NCAA,
Norwich,
Sunderland,
Sweet Sixteen,
Vols
Monday, February 17, 2014
Faith in science? Really?
My colleague Glenn Reynolds, who is a Distinguished Professor of Law at UTK, a prolific scholar, and runs the Instapundit website, has written a column for the New York Post warning of trusting scientists. While stating that "honestly done, science remans the best way of getting to the truth on a wide range of factual matters" he claims that "people are losing confidence in... scientists and the institutions that purport to speak for them". He goes on to state that "there's no particular reason why one should trust scientists and especially..the people running scientific institutions, who often aren't scientists themselves." [Glenn: minor point: while I'm loath to generalize, every scientific institution I know is indeed run by a scientist, albeit often one no longer active in research.] He suggests that scientists are often not skeptical enough and that it's the "increasing use of science as ammunition for big-government schemes" that has led to more skepticism of the public. He finishes off with the statement "If scientists want to be trusted, perhaps they should try harder to make sure that those who claim to speak for science are, you know, trustworthy. Just a thought."
So here is a response, from one who 'speaks for science'.
As in other highly-technical fields, such as medicine, to be a scientist requires a lot of learning and training; typically at least 10 years of undergraduate and graduate study. Normally, although aware that medical doctors have differing opinions and levels of competence, people do not trust someone without an M.D. to perform their heart surgery or fix their inflamed knee. So why not trust scientists?
Well, this particular inflammation is of political origin, and the statement about big-government science schemes is at the core. However, in my opinion, most people are in favor of some big-government science schemes while they may be against others. Consider, for example, a palette of projects: weapons research (such as the Manhattan Project) and other high-tech defense initiatives, blockbuster drug design, supercomputing, biotechnology, alternative energy and climate. None of these fields can advance (or could have advanced) rapidly without cooperative public and private investment - I'd be happy to explain why later for those who don't know. Which of these initiatives people classify as worthwhile tends to depend on their political and world view. But these biases are often out of fear for political decisions based on the science discovered, and this conflation of science and policy is at the origin of the mistrust.
Take our own Center for Molecular Biophysics as an illustration of the difference between the two. Quite a bit of our research is on biofuels or the environmental cycling of mercury. Yet we don't advocate any particular political policy related to these fields - indeed, we don't even discuss political aspects much. As for me, I don't necessarily approve unilaterally adopting a US carbon tax or regulating US mercury emissions; these policy decisions by themselves might in fact have no real effect on the problems they are trying to address. But, like Reynolds, I am no expert on these particular questions. I don't know what other members of CMB think.
But where we do agree with each other is that we think it's important to understand the science behind biofuel production, and how mercury is transformed and transported in the environment. And so we try to understand what is needed to find technological solutions to bring down the cost of cellulosic ethanol, and we try to to understand what happens to mercury once it enters the food web.
Myself, being a 'believer' in the general worth of science and technology for mankind, I want to see all the above-mentioned palette of projects pushed forwards. The cost to the taxpayer is small relative to other, non-science big-government schemes, and the economic return on investment enormous. Scientific research arms the population with the facts. What policy to adopt in response to the facts can then be chosen by the people and their representatives. But if you don't have the facts in the first place, on what do you base a political decision? So why defund climate research, or epidemiological research at NIH, or research on mercury cycling?
There's no reason to 'trust' scientists more than anyone else in their advocacy for any particular policy, but cutting down scientific research itself, which is surely the corollary of not trusting scientists in general, will lead to a lurch back towards an age of ignorance. Who then, would there be to trust?
So here is a response, from one who 'speaks for science'.
As in other highly-technical fields, such as medicine, to be a scientist requires a lot of learning and training; typically at least 10 years of undergraduate and graduate study. Normally, although aware that medical doctors have differing opinions and levels of competence, people do not trust someone without an M.D. to perform their heart surgery or fix their inflamed knee. So why not trust scientists?
Well, this particular inflammation is of political origin, and the statement about big-government science schemes is at the core. However, in my opinion, most people are in favor of some big-government science schemes while they may be against others. Consider, for example, a palette of projects: weapons research (such as the Manhattan Project) and other high-tech defense initiatives, blockbuster drug design, supercomputing, biotechnology, alternative energy and climate. None of these fields can advance (or could have advanced) rapidly without cooperative public and private investment - I'd be happy to explain why later for those who don't know. Which of these initiatives people classify as worthwhile tends to depend on their political and world view. But these biases are often out of fear for political decisions based on the science discovered, and this conflation of science and policy is at the origin of the mistrust.
Take our own Center for Molecular Biophysics as an illustration of the difference between the two. Quite a bit of our research is on biofuels or the environmental cycling of mercury. Yet we don't advocate any particular political policy related to these fields - indeed, we don't even discuss political aspects much. As for me, I don't necessarily approve unilaterally adopting a US carbon tax or regulating US mercury emissions; these policy decisions by themselves might in fact have no real effect on the problems they are trying to address. But, like Reynolds, I am no expert on these particular questions. I don't know what other members of CMB think.
But where we do agree with each other is that we think it's important to understand the science behind biofuel production, and how mercury is transformed and transported in the environment. And so we try to understand what is needed to find technological solutions to bring down the cost of cellulosic ethanol, and we try to to understand what happens to mercury once it enters the food web.
Myself, being a 'believer' in the general worth of science and technology for mankind, I want to see all the above-mentioned palette of projects pushed forwards. The cost to the taxpayer is small relative to other, non-science big-government schemes, and the economic return on investment enormous. Scientific research arms the population with the facts. What policy to adopt in response to the facts can then be chosen by the people and their representatives. But if you don't have the facts in the first place, on what do you base a political decision? So why defund climate research, or epidemiological research at NIH, or research on mercury cycling?
There's no reason to 'trust' scientists more than anyone else in their advocacy for any particular policy, but cutting down scientific research itself, which is surely the corollary of not trusting scientists in general, will lead to a lurch back towards an age of ignorance. Who then, would there be to trust?
Labels:
glenn reynolds,
Instapundit,
new york post,
science
Thursday, February 6, 2014
A Day in the Life of a Computational Chemist
My ex-graduate student, Zoe Cournia, writing on the Wiley Exchanges site "I live in a virtual reality world, where everything from chemical reactions to drugs, food, materials, cosmetics, electronics, and proteins is being modeled and simulated. And you won’t believe it, but, yes, I do have a job."
Labels:
computational chemistry,
Greece,
modeling,
simulation,
student
Saturday, February 1, 2014
Brawling and Bawling
So on January 28th I was in Norwich and watched the Canaries
take on Newcastle. The final score was a 0-0 tie. Sounds boring to aficionados of American sports,
in which it’s “No Ties Allowed”. But, in reality this game was 90 minutes of intensity
in a packed, passionate, partisan arena.
First up was Despair, as in the first half Newcastle were
all over us, streaming through the midfield, wave after wave of their highly technical
French strikers floating effortlessly down the wings past our full-backs. Men against
boys; no way were we going to survive this. Gloom. We would have even taken a
defeat, then, as long as they agreed not to humiliate us with a thrashing.
Frustration set in, with chants questioning certain
characteristics of the visiting fans. Then, our tempestuous Scottish winger Robert Snodgrass, who was having another bad game, fluffed a corner and got some
resounding abuse from most of our section of the crowd (the Snakepit).
Amazingly, the little brat retaliated! Swearing at us and gesturing! So, of course,
we shouted at him even more. How dare he?
We pay him a bloody Fortune (probably millions) and he has the gall to play
worse than a squashed haggis then cuss at us for tearing him off a strip! (Bet you wouldn’t see that happening in the NFL, either).
But Newcastle didn’t score; they hit the post three times,
our goalie was brilliant, and we did better in the second half, both teams
pushing, each giving 100%, desperately probing for the winner - end-to-end
stuff. Then our hard man, Bradley Johnson, tussled with Loic Remy. Johnson pushed
him, the Newcastle star might have headbutted him, Johnson went down and all
hell broke loose; all 22 players in a brawl, the whole stadium on fire, jubilation
as Remy was finally red carded then vitriol as, on reflection, the ref
inexplicably sent Johnson off as well.
Magnificent! But it wasn’t over – right at the end we twice
nearly sneaked an undeserved winner, grazing the bar then drawing an amazing save from
their keeper. Afterwards, Snoddy came back down to the Snakepit and applauded us
in contrition. We knew Snoddy gives everything - to quote Ray Hudson ‘working harder
than a one-eyed cat covering three mouse holes’. So we forgave him and the
evening finished in breathless mutual appreciation.
Labels:
bradley johnson,
loic remy,
NFL,
norwich city. soccer
Tuesday, January 28, 2014
Let's make a Love Drug!
Oxytocin is the love hormone, the magic chemical that creates warm, fuzzy feelings of bonding, trust, empathy and cuddle cravings. When someone's level of oxytocin goes up, he or she responds more generously and caringly, even with complete strangers. This is useful of course; for example, in the bar (chatting up a hot chick), or on the battlefield (making the Islamic Insurgents fall in love with their enemy). The problem is though, that oxytocin has to be injected, which is rather inconvenient, of course on a first date ("Excuse me, Cindy, just roll up your sleeve"?), and negotiating a ceasefire on the field for such a purpose is likely to prove nontrivial. So what is needed is something that one can just spray, or pop in a drink. That could be an oxytocin activator.
Now, how about this? Last week at a neutron workshop in UCSD I chatted with Bi-Cheng Wang of UGA, with whom I wrote a paper 15 years ago on the activation of oxytocin (Boris Velikson was my postdoc who did the modeling). On the bus at the airport we decided that all we need is to design a molecule that will do the activation (cleave the precursor at Arg2-Asp13) and voila! - beautiful people wherever you need them. Drug is the Love! Anyone having problems with the wife or got an obstreperous teenager? Maybe a dog that barks too much? Send the research dollars our way!!!
[Disclaimer: for all the spoil sports - yes, I know there are ethical problems with this type of thing, and, yes, I'm not serious, and, yes, I know there is already a oxytocin nasal spray being tested for autistic kids [but an activator may be more effective anyway]].
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