Wednesday, September 17, 2014

1707

"That the two Kingdoms of England and Scotland shall upon the First day of May which shall be in the year One Thousand Seven Hundred and Seven and for ever after be united into one Kingdom by the name of Great Britain And that the Ensigns Armorial of the said United Kingdom be such as Her Majesty shall appoint and the Crosses of St. George and St. Andrew be conjoyned in such manner as Her Majesty shall think fit and used in all Flags Banners Standards and Ensigns both at Sea and Land."

Saturday, September 6, 2014

The Age of Aerobatics


In the 1990s I lived with my family in Chateaufort-en-Yvelines, near Paris.

Three things you didn't know about Chateaufort:

- On 19 August 1913 Adolphe Pegoud  parachuted out of a plane from the Chateaufort airstrip. While descending, as he said, 'comfortably', he noticed his empty plane performing weird arabesques in the sky before crashing. This gave him the idea to fly a plane upside down, which he then did,  thus inventing aerobatics.

- Chateaufort has a little hill, which, though nothing like l'Alpe d'Huez, is still celebrated, as the last hill on the Tour de France.  We watched the Tour there in 1994. Arriving an hour before the riders were due, we waited three hours for their arrival, during which two storms passed over. After an inexorable parade of cars, they flew by, bunched, in a confusing flash.  I looked for the yellow jersey - there were five of them. In 1989 they erected a bronze stele at the top of the hill for Jacques Anquetil, the first cyclist to win the Tour five times. It was quickly stolen, presumably for the metal, and replaced with a less valuable version.

- Chateaufort has a restaurant called La Belle Epoque, which was one of the snootiest in the region when we lived there. When my ex-advisor, Martin Karplus at Harvard, asked where I lived, I replied that it was very small and he wouldn't have heard of it. He persisted, and when I told him he said "Wait a minute! Doesn't that have a nice restaurant?"

Friday, September 5, 2014

Why Elect judges?

One thing I never really understood about the USA is this need to elect judges. In Europe, where I come from, judges are by and large appointed according to how good they are for the job, rather than for political reasons. In other words, what counts is how well any prospective judge knows the law.  The politicians make the laws, and the judges simply decide whether these laws are being followed, don't they? Having elected judges certainly makes them accountable to the public, but how is there public to know who is a good or bad judge? Moreover,  candidate judges  have to bend to popular undercurrents and special interests.  A weird procedure. Hey, why not elect doctors and professors as well?

Tuesday, August 12, 2014

Wull Oi Dort Know 'Bout Tha' Rum Ole "Accent Reduction" Do

Oi see ORNL huz cancelled 'as "Suthern Accent Reduct'n" clarse.
Wull, Oi come frum Nawfolk in the UK, 'an um 'av'n fun 'ere tryun ter wroite  loike how Oi use ter speak over thar.

If yew can't picter ut 'ere's a video link ter 'ow 'ar Nawfolk Dumplin accent go.
Ass a sawng whut sold more 'an the Beatles or the Rolling Stones down our way..

Ar go'a say Oi wu'nt a gart no-where if Oi'd a kept that accent, so I s'pose I sor'a did a bit a accent reduc'n moiself - dort know zakly when, tho. Prob'ly at Leeds Uni, coz they sure as hell couldn't understand a good ole Nawfolk Dumplin dialect even there. So I s'pose the Suthen Accent Reduct'n thang at ORNL moite a bin a good thang - did summon loike 'ut moiself, yew see.

Saturday, July 19, 2014

A Special Pill Just for You





One of the many significant acts of my former advisor, Martin Karplus, was to help set up, in 1989, Vertex Pharmaceuticals -  one of the first companies to use a design strategy based on "rational", structure-based approaches.  Now, Kalydeco, designed by Vertex, is a glimpse into the future of personalized medicine. It is the first cystic fibrosis drug to treat the underlying cause of the disease, and works for those ~4% of patients with a certain mutation of an ion channel, which is potentiated by the drug. 4% amounts to about 2,000 patients, for whom this a wonder drug.  However, Vertex has slapped a $300,000+  yearly price tag on this drug, making it one of the most expensive in existence, and this has led to an understandable outcry from various sources, including some scientists involved in the development of the drug itself. In retort, Vertex point out that they have spent $6.5 billion on R&D that needs to be recouped and that it has only two drugs on the market.

Given that personalized medicine is aimed at ever smaller numbers of patients,  many fear that this approach will lead to ever more expensive drugs. But the one facet few seem to be talking about in this context is the origin of that  $6.5 billion number above. Most of that outlay will have been researching failures. Many of us are now trying to develop fast and efficient ways of finding drug candidates that are more likely than before to have high efficacy and safety.  This will get more personalized medicines to market quicker, with less R&D outlay. It stands to reason that if Vertex had discovered Kalydeco earlier, when its total R&D outlay had been only, say, $1 billion, then the price tag would have been lower.

It's not written in stone that personalized medicines will have to break the bank.

The Cost of Doing Business




Baudoin Prot: CEO BNP Paribas. Financier of the Year 2006, Recipient of the 'Social and Corporate Responsibility' Award of the Foreign Policy Association,  2007.


I like to see two sides to every story, but I have never really been particularly enamored of Western institutions aiding and abetting genocide. Recent examples of this include government support of East Timor, Guatemala, Kurdish Iraq and elsewhere, but the very latest in the news concerns the French bank BNP Paribas. According to the UN, between 2003 and 2007 the genocide in Darfur resulted in at least 200,000 deaths, principally civilians massacred by Sudanese government forces and the Janjaweed militia they supported.  The US had countering sanctions in place,  but these were flouted by  BNP Paribas for whom the lure of oil money was just too great. BNP  became the 'de facto Bank of Sudan', playing a 'pivotal role' in helping the Sudanese government sell oil in violation of the sanctions, funneling billions of dollars to the government, most of which bankrolled the military thugs. BNP covered it up for years. Eventually found guilty, the bank settled with the US for  $9bn a few days ago. BNP states it has ample funding to cover this. It's not going to perturb them too much. No individual has been charged. They will sleep soundly at night. As Forbes magazine states, banks  call this merely "the cost of doing business".

Thursday, July 10, 2014

How to Waste Taxes

Don't you love it when bureaucracy goes nuts? 

Here are  two cute examples from this week starring yours truly, both concerning travel reimbursements. 

No point in naming the organizations responsible;  one was state and the other federal;  nor in criticizing the administrators I interacted with, who were only following the rules, but; 

(1) A form was returned to me as invalid because I had claimed ONE CENT less than the amount on the receipts. 

Moral: Make sure we spend $100 of effort to correct a 1 cent mistake.

(2) A travel claim that has been bouncing around for two years (!) was finally definitively refused because, in a  attempt to save taxpayers' money on a flight, I had purchased a  round trip international ticket for $184 on a low-budget airline (Ryanair) that had only one  class. As no class was specified on the ticket this meant it couldn't be reimbursed. 

Moral: Let's make sure we discourage personal initiatives to save taxpayers' money.

Ole!